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Please try and find out what happened. But better still especially since you have begged her and she remains adamant, I feel you should pray and take authority over every wrong spirit influencing such strife. Please dont take this lightly, pray until you see your wife delivered from that oppressive spirit. When she gets better, lovingly talk over what enshewed, listen to her, then teach her why strife is dangerous to toil with in marriage. Both of you should come up with a suitable method of resolving your conflict, hurts or disagreement, get confessions for your marriage. Thats how to handle such and strenghten your marriage.